Short term oral administration of ANAVAR oxandrolone can stimula

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Short term oral administration of ANAVAR oxandrolone can stimulate the synthesis of male muscle proteins.
Sheffield Moore M、Urban RJ、Wolf SE、Jiang J、Catlin DH、Herndon DN、Wolfe RR、Ferrando AA。
Department of Surgery and Temple Burn Children's Hospital, University of Texas School of Medicine, Galveston, USA 77550. melmore@utmb.edu
Participants in the experiment: 6 healthy 22-year-old males, orally taking 15mg of Oxandrosaurus every day.
By analyzing the absorption status before and after. Using live muscle samples extracted from the femoral artery to obtain stable isotope data to determine the protein synthesis rate of the experimenter's muscles. The rate of catabolism is also included in the calculation. Measure the total messenger ribonucleic acid (mRNA) concentrations of insulin-like growth factor 1 (IGF-1) and androgen receptor (AR) in skeletal muscle using RT-PCR method.
Results obtained:
The muscle protein synthesis of the test source increased from 53.5+/-3 to 68.3+/-5 (average+/- SE) nmol/min.100 mL/leg (P<0.05), while protein breakdown remained unchanged. The absorption and utilization rate of amino acids in the body remains unchanged, while the excretion rate of amino acids decreases.
In addition, RT-PCR showed that ANAVAR oxandrolone significantly increased the mRNA concentration of skeletal muscle AR without altering the mRNA concentration of insulin-like growth factor (IGF-1).
The conclusion is that oxandrosaurus can stimulate an increase in skeletal muscle protein synthesis and intracellular reuse of amino acids in the short term. The mechanism of this stimulation is related to the increased expression of AR in skeletal muscles that can be induced by oxandrosaurus.