Testosterone, as the natural product drug and one of the most widely used
anabolic steroids, is the most convenient choice for a reference drug to which
all others will be compared. And while it is entirely possible to construct
maximally-effective steroid cycles without employing testosterone, most do not
do this, but instead use testosterone as their foundation. Either approach can
be entirely sound.
As a bodybuilding drug, testosterone is almost always used as an injectable
ester, due to poor oral bioavailability and the impracticality of high dose
transdermal or sublingual delivery. Testosterone also is provided as an
injectable suspension. Discussion here is in reference to these injectable
Pharmacologically, testosterone acts both via the androgen receptor and via
other means. In practice, it is found to combine synergistically both with those
anabolic steroids categorized as Class I and those categorized as Class II, and
therefore is described as having mixed activity.
Particular properties of testosterone that are of note include that it converts
enzymatically both to dihydrotestosterone (DHT) and to estradiol (the most
important of the estrogens.)
While with normal levels of testosterone and normal enzyme activity these
conversions are in fact desirable, with supraphysiological testosterone levels
caused by drug administration they can be undesirable. DHT is at least three
times more potent (effective per milligram) than testosterone at the androgen
receptor (AR): therefore, in those tissues which convert testosterone to DHT,
there is effectively three times as much androgen as elsewhere in the body.
Thus, whatever level of androgen is experienced by the muscle tissue is
effectively multiplied threefold or more in the skin and in the prostate. This
can be excessive.
Dutasteride (Avodart) can be used to keep DHT levels normalized despite heavy
testosterone use. Most users do not do this out of concern for excessively
reducing DHT, which may be a valid concern at full label dosing, but which I do
not think is a concern with low-dose use (½ tab every other day) in the context
of a high-dose testosterone cycle.
Finasteride (Proscar) may be employed instead, if one wishes to use a
5alpha-reductase inhibitor. In this case, in the context of a high-dose
testosterone cycle, one tab (5 mg) of this drug per day is unlikely to
excessively decrease DHT.
Excess conversion to estrogen is another undesirable occurrence since it
contributes to inhibition of the hypothalamic/pituitary/testicular axis (HPTA),
can cause or aggravate gynecomastia, can cause bloating, and can give
unfavorable fat pattern distribution. This conversion can be controlled by use
of aromatase inhibitors such as Arimidex or letrozole, and/or the effects of
excess estradiol may be blocked in relevant tissues by Clomid or Nolvadex.
Among the most significant differences of synthetic anabolic steroids compared
to testosterone is that they may avoid either or both of these enzymatic
conversions. In the past, this was a very important advantage. However, now that
these conversions can be well-controlled, high-dose testosterone need not have
all the adverse side effects that once inevitably accompanied its use.
Testosterone used as the sole androgen is capable of giving very effective
results, particularly with doses of one gram or more per week, and can give
substantial results with only 500 mg/week. If no other drugs are used to control
estrogen, however, side effects such as gynecomastia are fairly likely. Prostate
enlargement, acne or worsening of acne, and acceleration of male pattern
baldness (for those genetically susceptible to it) are more problematic with
testosterone – again, in the absence of enzymatic control — than with many
synthetics because of the effectively-higher androgen levels seen in these
tissues as a result of local conversion to the more-potent DHT.
So, to minimize these effects, the choices for a highly-effective cycle that is
low in side effects are to either control these enzymatic conversions with
ancillary compounds while using testosterone at high dose; to instead use
synthetics which do not undergo these conversions; or to combine moderate dose
testosterone (100-200 mg/week) with synthetics.
An anti-aromatase is preferable in a testosterone cycle to a selective estrogen
receptor modulator (SERM) such as Clomid or Nolvadex for controlling estrogen
because the SERMs either do nothing towards reducing effect of elevated estrogen
in aggravating or causing acne, or themselves contribute adversely.
Additionally, abnormally elevated estrogen levels may be deleterious for other
With regard to inhibition of the hypothalamic/pituitary/testicular axis (HPTA),
200 mg/week of injected testosterone is approximately 2/3 to 3./4 suppressive,
while 100 mg/week is about 50% suppressive. For this reason, low dose
testosterone use is not particularly efficient, as natural production is already
“worth” 100-200 mg/week, and this is mostly lost with the first 200 mg/week of
injectable that is used. The particular synthetics which are low-suppressive
are, for this reason, more efficient for low-dose use than is testosterone.
In terms of planning HPTA recovery after a cycle, for the above reason there is
little point in beginning post-cycle therapy (PCT) until testosterone levels
from the cycle have fallen to being commensurate with use of no more than about
200 mg/week. So for example, if using 800 mg/week, it would be advisable to wait
two half-lives. (After a number of days equal to the half life, levels will drop
to that commensurate with 400 mg/week use, and after that same number of days
again levels will again fall in half, now to levels to commensurate with 200
mg/week use.) So for example if the half-life of the ester used were 5 days, one
would wait till 10 days after the last injection to begin PCT, when the drug in
question is testosterone, due to the particulars of its suppressive properties.
With use of an anti-aromatase, 600-750 mg/week of injected testosterone is a
good dosage range for a novice. Without an anti-aromatase, it may be preferred
to limit usage to 500 mg/week, although there can be risk of gynecomastia at
doses even as low as 200 mg/week if no anti-estrogen is used. More advanced
users may favor one gram of testosterone per week. Still-higher doses such as 2
grams per week generally provide only a small further increment in performance,
with that generally being noticeable only if a plateau has been reached at 1
gram per week. Amounts higher than this are employed by some pro bodybuilders
but probably with only a slight further incremental effect.
This product was added to our catalog on Wednesday 17 June, 2020.